Kusajili – Centralise les essais cliniques mondiaux

Comparing Problem Solving Treatment combined with duloxetine with Problem Solving Treatment alone for patients with major depressive disorder in primary care The primary objective is assessing the depressive symptom reduction rate of mono-treatment (PST) compared to combined treatment (PST and duloxetine) in patients with major depressive disorder. In other words, testing the hypothesis that combined treatment is more effective than mono-treatment in patients with major depressive disorder.

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Temocillin use in Complicated Urinary Tract Infections due to ESBL producing and AmpC hyperproducing Enterobacteriaceae in United Kingdom Demonstrate efficacy and safety of temocillin in urinary tract infections due to Extended Spectrum Beta-Lactamases producing or AmpC hyperproducing Enterobacteriaceae.

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A study evaluating the safety and efficacy of MBX-8025 in subjects with Primary Biliary Cholangitis (PBC) and an inadequate response to or intolerance to ursodeoxycholic acid (UDCA) To evaluate the safety and efficacy of MBX-8025 2 mg, 5 mg, 10 mg, and 20 mg over 8 weeks of treatment

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Study to determine the appropriate age for a second immunization with the Meningococcal C conjugated vaccine - To assess serum MenC-PS specific IgG levels at T0 (prior to vaccination) and at 1 month (T1) and 1 year (T2) after the second MenCC vaccination and determine whether there is a difference in IgG levels between the different age groups (persistence of vaccine induced antibody levels) - To assess serum bactericidal antibody assay (SBA) levels at T0 and at 1 month (T1) and 1 year (T2) after the second MenCC vaccination and determine whether there is a difference between the different age groups in the levels and the proportion of participants that have an SBA level of ≥8 (persistence of vaccine induced protective antibody levels). - To assess avidity of serum IgG antibodies and determine whether there is a difference in avidity between the different age groups

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A randomized, Phase III study of Fotemustine versus the Combination of Fotemustine and Ipilimumab in Patients with Metastatic Melanoma with brain metastasis Studio randomizzato di fase III di confronto tra Fotemustina e la combinazione di Fotemustina e Ipilimumab in pazienti con Melanoma metastatico con metastasi cerebrali To compare the efficacy of the combination of ipilimumab and fotemustine versus fotemustine in terms of overall survival (OS) in patients with metastatic melanoma with brain metastasis Paragonare l’efficacia della combinazione ipilimumab più fotemustna vs fotemustina da sola in termini di sopravvivenza globale (OS) in pazienti con melanoma metastatico con metastasi cerebrali

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Study to evaluate the efficacy and safety of givinostat in ambulant patients with Duchenne Muscular Dystrophy. Estudio para evaluar la eficacia y la seguridad de givinostat en pacientes ambulantes con distrofia muscular de Duchenne (DMD) To establish the effects of givinostat versus placebo administered chronically over 18 months to slow disease progression in ambulant DMD subjects Establecer los efectos de givinostat en comparación con placebo cuando se administra de forma crónica durante más de 18 meses para frenar la progresión de la enfermedad en pacientes ambulantes con DMD.

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Pharmacokinetics of a single bolus of dexmedetomidine in ICU patients on continuous veno-venous haemodiafiltration Tutkimuksen tarkoitus on selvittää dexmedetomidiiniboluksen farmakokinetiikka jatkuvan hemodiafiltraation aikana.

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The use of human albumin for the treatment of ascites in patients with hepatic cirrhosis: A multicenter, open-label randomized clinical trial Primary objectives are: - increase in survival - improvement in the response to standard medical treatment and avoid/delay the occurrence of refractory ascites in patients with cirrhosis and uncomplicated ascites.

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Multicentric phase II trial to evaluate the efficacy and safety of Ibrutinib in combination with rituximab in patients with indolent clinical forms of Mantle Cell Lymphoma. Ensayo clínico Fase II multicéntrico para evaluar la eficacia y seguridad de Ibrutinib en combinación con rituximab en pacientes con formas clínicas indolentes de Linfoma de Células del Manto To explore the efficacy of Ibrutinib plus Rituximab combination as a therapeutic alternative to immuno-chemotherapy (R-CHOP regimen) in indolent forms of Mantle Cell Lynphoma (MCL) by assessing the rate of complete responses achieved at 12 months of treatment Explorar la eficacia de la combinación I+R como una alternativa terapéutica a la inmunoquimioterapia (régimen R- CHOP) en formas clínicas indolentes de LCM, mediante la determinación de la tasa de respuestas completas alcanzadas a los 12 meses de tratamiento.

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Treatment of pregnant women with iron deficiency anemia The primary objective of the trial is to evaluate and compare the effect of IV iron isomalto-side to a fixed dose of oral iron administered as tablet ferrous fumarate with ascorbic acid as correction of anaemia in pregnant women who have IDA after 4 weeks of standard treatment.

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